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Population-specific Risk of Pharmacogenomics-related Inaccurate Drug Dosing of ICU Patients
2025-02-14
genetic and genomic medicine
Title + abstract only
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RationaleIntensive care units (ICU) patients are highly vulnerable to inaccurate drug dosing. Pharmacogenomics (PGx) characterizes the influence of inherited genetic variation on drug metabolism, playing an important role in the consequences of a given drug dose. ObjectivesTo assess the genetic-based risk of inaccurate drug dosing in the ICU. MethodsWe carried out whole genome sequencing (WGS) of 210 Qataris in ICU care at Hamad Medical Corporation (HMC), Doha, Qatar and assessed the WGS for p...
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