Acute exercise rewires the proteomic landscape of human immune cells
Walzik, D.; Joisten, N.; Metcalfe, A. J.; Proschinger, S.; Schenk, A.; Wenzel, C.; Henneberg, A. L.; Schneider, M.; Calderazzo, S.; Groll, A.; Watzl, C.; Opitz, C.; Helm, D.; Zimmer, P.
Show abstract
Exercise-driven alterations of the immune system are a key mechanism in the prevention and treatment of various diseases. Here, we performed mass spectrometry-based proteomics analysis on peripheral blood mononuclear cells (PBMCs) at a depth of >6000 proteins. Comparing time- and workload-matched high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE) we discover versatile changes in the proteomic makeup of PBMCs and reveal profound alterations related to effector function and immune cell activation pathways within one hour after exercise. These changes were more pronounced after HIIE compared to MICE and occurred despite identical immune cell mobilization patterns between the two exercise conditions. We further identify an immunoproteomic signature that effectively predicts cardiorespiratory fitness. This study provides a reliable data resource that expands our knowledge on how exercise modulates the immune system, and delivers biological evidence supporting the WHO 2020 guidelines, which highlight exercise intensity as a relevant factor to maintain health.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Exercise Training and Cold Exposure Trigger Distinct Molecular Adaptations to Inguinal White Adipose Tissue 96%
- Proteomic analysis of circulating immune cells identifies novel cellular phenotypes associated with COVID-19 severity 93%
- Exercise Training Remodels Adipocyte-Specific Extracellular Matrix Proteins and Alters Innervation and Vascularization in Inguinal White Adipose Tissue (iWAT) 93%
Similar papers in this journal
- Comprehensive cell surface proteomics defines markers of classical, intermediate and non-classical monocytes 93%
- Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis 93%
- Regulators of TNFα Mediated Insulin Resistance Elucidated by Quantitative Proteomics 93%
Similar papers in this journal
Similar papers in this journal
- Integration of Multiomic and Multi-phenotypic Data Identifies Biological Pathways Associated with Physical Fitness 94%
- Molecular programming in utero modulates hepatic lipid metabolism and adult metabolic risk in obese mother offspring in a sex-specific manner 92%
- AutoFocus: A hierarchical framework to explore multi-omic disease associations spanning multiple scales of biomolecular interaction 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.