Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatment
Zhang, X.-S.; Wang, Y.; Sun, H.; Zerbe, C.; Falcone, E.; Bhattacharya, S.; Zhang, M.; Gao, Z.; Diaz-Rubio, M. E.; Bharj, D.; Patel, D.; Pan, S.; Ro, G.; Grenard, J.; Armstrong, A.; Yin, Y. S.; Dominguez-Bello, M. G.; Holland, S.; Su, X.; Blaser, M. J.
Show abstract
The gut microbiome influences immune and metabolic homeostasis. Our research using non-obese diabetic (NOD) mice revealed that early-life antibiotic exposure remodels the gut microbiome affecting metabolism and accelerating type 1 diabetes (T1D) incidence, with cecal material transplant (CMT) mitigating the damage. Now examining murine intestinal lipidomic profiles, we identified 747 compounds. Comparing the lipidomic profiles of cecal contents of conventional and germ-free mice and their diets, we identified 87 microbially-produced lipids reduced by antibiotic exposure but CMT-restored. Parallel analysis of human fecal lipid profiles after azithromycin-exposure showed significant alterations with substantial overlap with mice. In vitro co-culture with mouse macrophages or small intestinal epithelial cells and human colonic epithelial cells identified phospholipids that repress inflammation through the NF{kappa}B pathway. Oral administration of these phospholipids to antibiotic-treated NOD mice reduced expression of ileal genes involved in early stages of T1D pathogenesis. These findings indicate potential therapeutic anti-inflammatory roles of microbially-produced lipids.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model 97%
- Gut microbiome shifts in adolescents after sleeve gastrectomy with increased oral-associated taxa and pro-inflammatory potential 96%
- Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism 96%
Similar papers in this journal
- Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism 97%
- Dietary protein increases T cell independent sIgA production through changes in gut microbiota-derived extracellular vesicles 96%
- Biosynthetic Enzyme-guided Disease Correlation Connects Gut Microbial Metabolites Sulfonolipids to Inflammatory Bowel Disease Involving TLR4 Signaling 96%
Similar papers in this journal
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice 96%
- Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice 95%
- A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis 95%
Similar papers in this journal
- Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells 94%
- A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis 94%
- Metabolite mimicry identifies butyrate analogs with select protective functions in the intestinal mucosa 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.