Genetic polymorphism and risk of anti-tuberculosis drug-induced liver injury (AT-DILI): a systematic review and meta-analysis

2025-01-20 pharmacology and therapeutics Title + abstract only

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Anti-tuberculosis (TB) drugs like isoniazid and rifampin can cause hepatotoxicity leading to treatment termination. Although Genome-wide association studies (GWAS) have identified variants linked to the risk of developing anti-tuberculosis drug-induced liver injury (AT-DILI), findings remain inconsistent. This study aimed to systematically summarise previous observational studies and assess the association between genetic polymorphisms and AT-DILI risk in adults. We conducted a comprehensive se...

Genetic polymorphism and risk of anti-tuberculosis drug-induced liver injury (AT-DILI): a systematic review and meta-analysis

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