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Over-expressed KRT8 in the cytotrophoblast shell promotes the development of preeclampsia
2025-01-09
obstetrics and gynecology
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Preeclampsia is a "placenta-derived disorder" characterized disease, which remains a major unaddressed public health problem. The differentiation and development of cytotrophoblasts and extravillous trophoblasts are two crucial processes, which are tightly regulated. And any abnormal regulation can lead to the occurrence of pregnancy-related diseases such as preeclampsia. In this article, we performed Spatial transcriptomics on tissues of PE and Normal, and found a large amount of extravillous t...
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