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Multiomic Mendelian randomization-based insights into the role of neutrophil extracellular trap-related genes in sepsis

2024-12-27 intensive care and critical care medicine Title + abstract only
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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of sepsis, yet the precise role of NET-related genes (NRGs) remains unclear. This study employed a multiomic Mendelian randomization (MR) approach, leveraging genetic variants as instrumental variables to investigate the relationships between NRGs and sepsis risk. We systematically identified 69 NRGs based on literature...

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