Cisplatin resistance reversal with treatment of Citric acid in cisplatin-resistant cell lines
Chaturvedi, S.; Venka, K.
Show abstract
Gastric cancer (GC) is a prevalent and aggressive malignancy with significant morbidity and mortality rates, posing a major threat to human health globally. While surgery remains the preferred clinical treatment, chemotherapy continues to be the cornerstone for perioperative care, adjuvant therapy, and palliative treatment for patients with advanced stages of GC. Among the chemotherapeutic agents, cisplatin (DDP) has been widely used for decades as a first-line treatment for various solid tumors. However, its therapeutic efficacy is frequently undermined by the development of resistance, which is attributed to the complex interplay of multiple proteins and signaling pathways involved in the resistance mechanisms. In this study, the issue of cisplatin resistance is addressed by employing citric acid as a treatment in cell lines. The findings demonstrate that citric acid effectively reverses cisplatin resistance, suggesting the potential involvement of a novel DNA damage repair mechanism. These results pave the way for further investigation into innovative therapeutic approaches to enhance the efficacy of cisplatin in treating gastric cancer.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Research of the mechanism on miRNA193 in exosomes promotes cisplatin resistance in esophageal cancer cells 96%
- A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin 95%
- Application of non-invasive low-intensity pulsed electric field with thermal cycling-hyperthermia for synergistically enhanced anticancer effect of chlorogenic acid on PANC-1 cells 95%
Similar papers in this journal
- The mitochondrial deubiquitinase USP30 regulates AKT/mTOR signaling 94%
- Development of a Novel Bruton's Tyrosine Kinase Inhibitor that exerts Anti-Cancer Activities Potentiates Response of Chemotherapeutic Agents In Multiple Myeloma Stem Cell-Like Cells 92%
- Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma 92%
Similar papers in this journal
- Tegaserod maleate suppresses the growth of gastric cancer in vivo and in vitro by targeting MEK1/2 97%
- Loss of CHGA protein as a potential biomarker for colon cancer diagnosis: a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays 94%
- A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 93%
Similar papers in this journal
- HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells 96%
- Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoid in lipopolysaccharide-treated HEI-OC1 cells through modulation of Foxp3/Nrf2 signaling pathway 93%
- Melatonin alleviates valproic acid-induced neural tube defects by modulating Src/PI3K/ERK signaling and oxidative stress 92%
Similar papers in this journal
- siRNA-based Therapeutic Candidate Targeting PRDM2 for Inhibition of Lung Cancer Progression 94%
- Molecular classification reveals the diverse genetic features and prognosis of gastric cancer: a multi-omics consensus ensemble clustering 94%
- JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.