Sotalol dose optimization for fetal tachycardia: a pregnancy physiologically based pharmacokinetic model study.

2024-12-20 pharmacology and therapeutics Title + abstract only

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ObjectiveTo establish an optimized sotalol dosing strategy for fetal tachycardia by using a pregnancy computational model for dose simulations. MethodsA physiologically-based computational model, including pregnancy-related changes and placental transfer values, was established and verified. Simulations of the current dosing advises and prospective dosing scenarios were performed. To avoid maternal dose-related toxicity (QT-prolongation) we aimed for maternal concentrations <2.5 mg/L. Based on ...