Intermittent fasting alters tumor burden, autophagy, and metabolites in chronic lymphocytic leukemia
Stringer, E. J.; Wei, Z.; Punch, S.; Costie, N.; Han, J.; Goodlett, D. R.; Nathoo, F. S.; Lum, J. J.; MacPherson, N.
Show abstract
Emerging preclinical data suggests dietary interventions, including intermittent fasting, may play a key role in altering cancer progression. In a feasibility trial monitoring cellular, clinical, and qualitative changes, ten patients with chronic lymphocytic leukemia followed time-restricted eating for three months, and five patients for six months. Seven of fifteen participants (47%) experienced a decrease or stabilization in malignant lymphocyte counts on time-restricted eating, while malignant lymphocyte accumulation slowed in five participants (33%) or had no effect in three participants (20%). A reduction in malignant lymphocyte counts were accompanied by an unexpected decline in cellular autophagy in malignant lymphocytes. Metabolite profiling identified microbial-derived bile acid metabolites, glycoursodeoxycholic, taurochenodeoxycholic, glycolithocholic and ursodeoxycholic acid, and short-chain fatty acids, dehydrolithocholic and apocholic acid, that changed with time-restricted eating. Participant quality of life improved during time-restricted eating. These results connect time-restricted eating with shifts in autophagy, microbial-derived metabolites, tumor progression, and quality of life.
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