Back

Intratympanic cortisone injection: an evaluation of the current data situation

Schmidt, S.; Thomsen, M.; Lorenz, K. J.

2024-12-06 intensive care and critical care medicine
10.1101/2024.12.05.24318568 medRxiv
Show abstract

IntroductionIntratympanic cortisone injections (ITI) have been established for sudden deafness for years. ITI can be used as primary therapy and, above all, as rescue therapy if systemic administration has not brought any improvement or if there are contraindications to systemic administration. MethodsMany different forms of application, indication, duration and treatment have been used. Different local anesthetics, cortisone preparations, body and head positions are practiced. Results103 patients are analyzed. In 55 cases, the injection after oral therapy. In 48 cases, given immediately due to extreme hearing loss or comorbidities the injections are well tolerated with rare unpleasant side effects. DiscussionHigh-dose treatment with cortisone has been used for decades. The HODOKORT study brought significant dose reductions. The KORTEBO study could not be carried out, but there is need for it. There is a lack of evidence of an optimal indication, implementation and objective proof, which is urgently needed.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.