Causal relationship between inflammatory cytokines, metabolites and arrhythmia: a mendelian randomization study
Xie, f. y.; tang, l.; huang, f.; Zeng, Z.
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AbstractO_ST_ABSBackgroundC_ST_ABSThis study aims to explore the causal relationships between inflammatory cytokines (ICs), metabolites, and the risk of arrhythmia through Mendelian Randomization (MR) analysis. MethodsThe causal associations were analyzed using five different MR analysis methods. Additionally, reverse MR analysis was performed to assess the impact of arrhythmias on these ICs and their metabolites. ResultsThe MR analysis revealed that Oncostatin-M receptor (OSM) was significantly associated with an increased risk of arrhythmia (OR = 1.0812, p < 0.05), along with other ICs such as CXCL11 (OR = 1.0586), SIRT2 (OR = 1.0521), and FGF5 (OR = 1.0520). Five were positively correlated with arrhythmia risk, including X-22776 (OR = 1.071, p = 0.022) and tricosanoylsphingomyelin (OR = 1.066, p = 0.035).Mediation analysis demonstrated that FGF5 influences arrhythmia risk through its metabolite 1-palmitoyl-2-oleoyl-GPE, with a mediated effect accounting for 5.1% of the total effect. ConclusionsOur findings suggest that specific ICs and metabolites contribute to the pathogenesis of arrhythmia. In particular, FGF5 and its metabolite 1-palmitoyl-2-oleoyl-GPE are implicated in increased arrhythmia risk, highlighting potential metabolic targets for therapeutic intervention.
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