Cohort Profile Update: Expanding the Cardiovascular Risk in Young Finns Study into a multigenerational cohort
Pahkala, K.; Rovio, S.; Auranen, K.; Bourgery, M.; Elovainio, M.; Fogelholm, M.; Haapala, J.; Hirvensalo, M.; Hutri, N.; Jokinen, E.; Jula, A. M.; Juonala, M.; Kaikkonen, J.; Kartiosuo, N.; Kiviranta, H.; Koskinen, J. S.; Kotaja, N.; Kahonen, M.; Laitinen, T. P.; Lehtimaki, T.; Lisinen, I.; Loo, B.-M.; Lyytikainen, L.-P.; Magnussen, C. G.; Mishra, P. P.; Mykkanen, J.; Makela, J.-A.; Mannisto, S.; Nevalainen, J.; Pulkki-Raback, L.; Raitoharju, E.; Rantakokko, P.; Ronnemaa, T.; Stenbacka, S.; Taittonen, L.; Tammelin, T. H.; Toppari, J.; Tossavainen, P.; Viikari, J.; Raitakari, O.
Show abstract
Cardiovascular Risk in Young Finns Study (YFS) is a prospective cohort of 3596 males and females (baseline age 3-18 years) that was established in 1980 to study cardiovascular risk factors in children and adolescents. The YFS has been instrumental in demonstrating the links between childhood risk factors and adult cardiovascular outcomes with implications on paediatric cardiovascular preventive practise. In the latest follow-up in 2018-2020, the study was expanded into a three-generation cohort, including the original cohort members, as well as their parents and offspring. Altogether 7341 individuals aged 3-92 years participated; 2127 original cohort members (now aged 40-58 years), 2452 parents (aged 58-92 years) and 2762 offspring (aged 3-37 years) of the original cohort members. The main aim was to establish a multigenerational population data base, sample biobank and links to national health registries that would offer a unique platform to study familial transmission of health-related traits. The field studies and data collections were conducted as part of the ERC funded MULTIEPIGEN project designed testing a specific hypothesis that epigenetic markers in the semen play a role in the transmission of intergenerational information in the paternal lineage. It is a first a priori designed epidemiologic study assessing the role of paternal life exposures, including chemical and psychosocial stress, in the development of cardio-metabolic, cognitive and psychosocial outcomes in their offspring.
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