Primary Central Nervous System Lymphoma Tumor Biopsies Show Heterogeneity in Gene Expression Profiles, Genetic Subtypes, and in vitro Drug Sensitivity to Kinase Inhibitors
Zhu, Y. X.; Wong, J. C.; Hilal, T.; Maguire, A.; Ocal, J.; Zellner, K.; Chen, X.; Link, B. K.; Habermann, T. M.; Maurer, M. J.; Cerhan, J. R.; Johnston, P. B.; Feldman, A. L.; Scott, D. W.; Rosenthal, A.; Rimsza, L.
Show abstract
BackgroundPrimary central nervous system lymphoma (PCNSL) is clinically challenging due to its location and small biopsy size, leading to a lack of comprehensive molecular and biologic description. We previously demonstrated that 91% of PCNSL belong to the activated B-cell-like (ABC) molecular subtype of diffuse large B-cell lymphoma (DLBCL). MethodsHere we investigated the expression of 739 cancer related genes in HIV(-) patients in 25 ABC-PCNSL and 43 ABC-systemic DLBCL, all tumors were EBV(-). ResultsWe found 135 genes which were identified as differentially expressed between these ABC-PCNSL and ABC-systemic DLBCL (p<0.05). The ABC-PCNSL showed higher gene expression in several cancer-related gene sets including genes related to Hedgehog, DNA damage repair, Wnt and MAPK signaling. Whole exome sequencing showed distinct genetic features of PCNSL compared to DLBCL, CXCR4 mutations in particular, that have been associated with ibrutinib resistance. In a focused analysis, PCNSL and DLBCL cases that fall into the "MCD" genetic subtype showed substantial overlap. These data provide detailed information about unique characteristics of PCNSL in HIV(-) patients as compared to comparable DLBCL subtypes.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- High-grade B-cell lymphoma, not otherwise specified: an LLMPP study 95%
- Single-cell profiling identifies clinically relevant interactions between tumor associated macrophages and blood endothelial cells in diffuse large B cell lymphoma 95%
- Single-cell spatial analysis of tumor immune architecture in diffuse large B cell lymphoma 95%
Similar papers in this journal
- RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia 92%
- Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers 92%
- Interrogating the Precancerous Evolution of Pathway Dysfunction in Lung Squamous Cell Carcinoma Using XTABLE 91%
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Unraveling the heterogeneous mutational signature of spontaneously developing tumors in MLH1-/- mice 93%
- Canine oral melanoma genomic and transcriptomic study defines two molecular subgroups with different therapeutical targets 92%
- ATRX alteration contributes to tumor growth and immune escape in pleomorphic sarcomas 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.