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Impacts of receptor binding and immunity on SARS-CoV-2 fitness landscape: a modeling study

Ding, Z.; Yuan, H.-Y.

2024-10-27 infectious diseases
10.1101/2024.10.24.24316028 medRxiv
Show abstract

Despite extensive research on SARS-CoV-2 ACE2 binding and transmissibility, their relationship concerning varying immunity remains unclear. SARS-CoV-2 RBD sequences from Italy in GISAID, combined with multiple deep mutational scanning data, were used to calculate ACE2 binding score and immune escape during the pandemic. We developed a COVID-19 transmission model that decomposed the effective reproduction number into three time-varying components: viral infectiousness (representing fitness), host susceptibility, and contact rate. After model fitting, a rugged fitness landscape, spanned by ACE2 binding score and virus-perceived effective immunity (adjusted for viral immune escape), was observed with peaks corresponding to individual VOCs (alpha, delta, and omicron (BA.1* and BA.2*)). Increasing effective immunity with reduced ACE2 binding corresponded to decreasing virus fitness peaks from alpha to delta. Among omicron sub-lineages, which exhibited enhanced immune escape, BA.2* reached a fitness optimum while retaining slightly reduced ACE2 binding relative to BA.1.1. The findings help explain the evolution of SARS-CoV-2.

Published in iScience (predicted rank #2) · training set

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