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Diffuse fibrosis, coronary microvascular dysfunction and systolic dysfunction in Wilson disease

2024-10-15 cardiovascular medicine Title + abstract only
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BackgroundWilson disease (WD) causes intracellular copper accumulation in the body due to a genetic defect in the protein ATP7B. Cardiac involvement such as electrocardiographic abnormalities, rhythm abnormalities, heart failure and cardiac death have been reported, however pathophysiological mechanisms remain unclear. ObjectivesThis study aimed to comprehensively assess the myocardium in WD patients without cardiac symptoms using multiparametric cardiovascular magnetic resonance imaging (CMR),...

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