Genetic Association of Glutathione S-Transferase Omega 2 (GSTO2) Gene Variant (rs156697) with Chronic Kidney Disease Patients of Pakistani Origin
Afzal, A.; Saif, R.; Atta, A.; Jafri, S. A.; Naqvi, S. K. A.
Show abstract
Chronic Kidney Disease (CKD) poses a significant global health challenge. The kidneys can be compromised by internal diseases, environmental influences and various genetic factors. Among the genetic factors, particularly, GSTO2 gene plays a crucial role in cellular processes and enzyme performance, which can lead to interstitial kidney damage and contribute to CKD. The current study investigates the genetic association between the GSTO2 gene variation (rs156697) and CKD in the Punjabi community. This study examined the association between the GSTO2 gene locus (c.424A>T) and CKD in a Punjabi population using ARMS-PCR genotyping. A total of 50 samples were analyzed, revealing 19 homozygous wild-type, 25 heterozygous and 6 homozygous mutants. PLINK data analysis toolset indicated an insignificant genotypic association with CKD phenotype with observed p-value of 0.7177 and an odds ratio of 0.85. Similarly, the alternative allele frequency of 0.34 and 0.375 was also observed in CKD and normal controls respectively. In the future, further studies with more genetic markers along with functional studies with large sample data may be performed for robust statistical evidence of the association of subject gene with CKD patients in Pakistan.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Kidney Damage and Associated Risk Factors in the Rural Eastern Cape, South Africa: A Cross-Sectional Study 98%
- Revisiting the Association between Human Leukocyte Antigen and End-Stage Renal Disease 97%
- Demographic and clinical profile of black patients with chronic kidney disease attending Charlotte Maxeke Johannesburg Academic Hospital (CMJAH) in Johannesburg, South Africa. 96%
Similar papers in this journal
- Analysis of serum trace elements, macro-minerals, antioxidants, malondialdehyde and immunoglobulins in seborrheic dermatitis patients: A case-control investigation 94%
- A small H2O-soluble ingredient of royal jelly lower cholesterol levels in liver cells by suppressing squalene epoxidase 93%
- Improvement of Survival Outcomes of Cholangiocarcinoma by Ultrasonography Surveillance: Multicenter Retrospective Cohorts 92%
Similar papers in this journal
- Gene expression profiles and pathway enrichment analysis to identification of differentially expressed gene and signaling pathways in epithelial ovarian cancer based on high-throughput RNA-seq data 91%
- Comparative Analysis of Human Coronaviruses Focusing on Nucleotide Variability and Synonymous Codon Usage Pattern 91%
- Genome-wide interologous interactome map (TeaGPIN) of Camellia sinensis 90%
Similar papers in this journal
- In silico analysis of SNPs in human phosphofructokinase, Muscle (PFKM) gene: An apparent therapeutic target of aerobic glycolysis and cancer 94%
- Interleukin- 10 (IL-10) gene polymorphisms and prostate cancer susceptibility: evidence from a meta-analysis 94%
- Identification of Dysregulated Pathways and key genes in Human Retinal Angiogenesis using Microarray Metadata 92%
Similar papers in this journal
- Correlations between individual factors, meteorological factors, and hemorrhagic fever with renal syndrome in the Tai'an area of China 94%
- Pool walking may temporarily improve renal function by suppressing renin-angiotensin-aldosterone system in pregnant women 93%
- Estimation of the Hemoglobin Glycation Rate Constant 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.