Lifestyle Profiling Using Wearables and Prediction of Glucose Metabolism in Individuals with Normoglycemia or Prediabetes
Snyder, M.; Park, H.; Metwally, A. A.; Delfarah, A.; Wu, Y.; Perelman, D.; Rodgar, M.; Mayer, C.; Celli, A.; McLaughlin, T.; Mignot, E.
Show abstract
This study examined the relationship between lifestyles (diet, sleep, and physical activity) and glucose responses at a personal level. 36 healthy adults in the Bay Area were monitored for their lifestyles and glucose levels using wearables and continuous glucose monitoring (NCT03919877). Gold-standard metabolic tests were conducted to phenotype metabolic characteristics. Through the lifestyle data (2,307 meals, 1,809 nights, and 2,447 days) and 231,206 CGM readings from metabolically-phenotyped individuals with normoglycemia or prediabetes, we found: 1) eating timing was associated with hyperglycemia, muscle insulin resistance (IR), and incretin dysfunction, whereas nutrient intakes were not; 2) timing of increased activity in muscle IS and IR participants was associated with differential benefits of glucose control; 3) Integrated ML models using lifestyle factors predicted distinct metabolic characteristics (muscle, adipose IR or incretin dysfunction). Our data indicate the differential impact of lifestyles on glucose regulation among individuals with different metabolic phenotypes, highlighting the value of personalized lifestyle modifications.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Plasma proteomic signatures of adiposity are associated with cardiovascular risk factors and type 2 diabetes risk in a multi-ethnic Asian population 93%
- β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice 93%
- Characterizing common and rare variations in non-traditional glycemic biomarkers using multivariate approaches on multi-ancestry ARIC study 93%
Similar papers in this journal
- Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population 95%
- Novel mediation analysis of human plasma proteome and metabolome reveals mediators of improved glycemia after gastric bypass surgery 94%
- Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer&aposs disease 93%
Similar papers in this journal
- Metabolome-defined obesity and the risk of future diabetes and mortality 95%
- Assessing the causal role of sleep traits on glycated haemoglobin: a Mendelian randomization study 93%
- Poor in-utero growth, reduced beta cell secretion and high plasma glucose in childhood are harbingers of glucose intolerance in young Indians 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.