Identification of leptolin as a novel anti-obesity adipokine
Liu, J.; Wang, B.; Su, Z.; Han, X.; He, M.; Zhao, Y.; Hou, Y.; Li, D.; Zhang, W.; Qin, L.; Wang, K.; Li, Y.; Yan, Y.; Yu, S.; Huang, X.; Yuwen, T.; Zheng, R.
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Adipokines are key factors in regulating energy homeostasis. We identified a novel adipokine; we named it Leptolin. In humans, leptolin levels in white adipose tissue were positively corrected with exercise, and negatively associated with body mass index. Leptolin levels were positively correlated with lipolysis-promoting gene expression. Elevated leptolin in plasma of athletes, whereas lowered leptolin in plasma of obese individuals were observed. Leptolin gene-knockout mice exhibited increased adiposity and body weight, and decreased energy expenditure. Leptolin gene-overexpression mice showed obesity-resistant phenotypes. Treatment with leptolin promoted fat mobilization and energy expenditure, and reduced body weight, without affecting food-intake and motor activity. Together, leptolin, a novel adipokine with a capacity to improve metabolic status, may serve as a new therapeutic agent for obesity and metabolic disorders.
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