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Switching on Behavioral and Neural Rhythmicity to Retrieve Memories When the Number of Retained Items Exceeds Four

Ideriha, T.; Ushiyama, J.

2024-09-01 neuroscience
10.1101/2024.08.31.610596 bioRxiv
Show abstract

Even when we experience difficulty in recalling memories, we nevertheless manage to retrieve the target items. However, the neural mechanisms that enable such difficult memory retrieval are unknown. Here, we report an intriguing phenomenon where our nervous system "switches on" behavioral/neural rhythmicity to retrieve memory when the number of candidate items exceeds four. In our experiments, participants learned and retrieved 2-5 color/letter pairs. Analyses of hundreds of reaction times revealed a significant tendency for memory recall to occur at discrete times corresponding to theta-alpha (4-13 Hz) cycles, but only when the number of memorized pairs exceeded four. Electrophysiological data localized theta-alpha rhythmicity around parietal electrodes, a region associated with the long-term memory system. Our findings suggest that neural rhythmicity facilitates memory retrieval when the number of candidate items exceeds four, which is known as the "magical number" corresponding to the limit of human cognitive capacity.

Published in Scientific Reports (predicted rank #1) · training set

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