A nuclear hormone receptor nhr-76 programs age-dependent chemotaxis decline in C. elegans
Yokosaka, R.; Noma, K.
Show abstract
A decline in food-searching behavior of post-reproductive animals can be beneficial for the population and possibly programmed by the genome. We investigated the genetic program of age-dependent decline in chemotaxis behavior toward an odorant secreted from bacterial food in C. elegans. Through a forward genetic screen, we identified a nuclear hormone receptor, nhr-76, whose mutants ameliorate the age-dependent chemotaxis decline. We found that nhr-76 downregulates the expression of the odorant receptor during aging. Because NHR-76 expression and localization did not change during aging, secretion of its hydrophobic ligands might alter the activity of NHR-76 to cause age-dependent chemotaxis decline. Our findings imply that post-reproductive behavioral decline can be genetically programmed.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in C. elegans 94%
- Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans 94%
- Diets affect the age-dependent decline of associative learning in Caenorhabditis elegans 94%
Similar papers in this journal
- Analysis Of Chd-7 Defective Dauer Nematodes Implicates Collagen Misregulation In Charge Syndrome Features. 95%
- The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity 94%
- A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons 93%
Similar papers in this journal
- The Clock:cycle complex is a major transcriptional regulator of Drosophila photoreceptors that protects the eye from retinal degeneration and oxidative stress 95%
- Locus-specific H3K9me3 gain in aged somatic tissues in Caenorhabditis elegans 93%
- LIPL-1 and LIPL-2 are TCER-1-regulated Lysosomal Lipases with Distinct Roles in Immunity and Fertility 93%
Similar papers in this journal
Similar papers in this journal
- Reduction of DNA Topoisomerase Top2 reprograms the epigenetic landscape and extends health and life span across species 95%
- Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons 93%
- Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.