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Comment to: "Topology of molecular deformations induces triphasic catch bonding in selectin-ligand bonds"

Quapp, W.; Bofill, J. M.

2024-08-23 biochemistry
10.1101/2024.08.21.608529 bioRxiv
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We contradict diverse mathematical claims of a paper by Casey O. Barkan and Robijn F. Bruinsma in PNAS 2024, 121, No. 6, e2315866121, former BioRxiv preprint from Sept.12,2023. It deals with the physical mechanisms of protein-ligand catch bonding for the family of selectin proteins. Selectins exhibit slip, catch-slip, and slip-catch-slip bonding.

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