Integrative Multi-omics Approach Reveals the Molecular Characterization and Differences of ECM-PI3K-Akt Pathway among Coronary Artery Bypass Grafting Conduits with Clinical Implications

2024-08-14 cardiovascular medicine Title + abstract only

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BACKGROUNDA key problem for results of coronary artery bypass grafting (CABG) is different long-term patency of grafts (internal mammary artery [IMA], radial artery [RA], and saphenous vein [SV]). METHODS AND RESULTSWe investigated the biological differences among IMA-SV, RA-SV, and IMA-RA using multi-omics approaches in order to explore new therapeutic targets. Trios of the human IMA, RA, and SV (n=72) from the CABG patients were studied using transcriptomics and proteomics. Differential mRNAs...

Integrative Multi-omics Approach Reveals the Molecular Characterization and Differences of ECM-PI3K-Akt Pathway among Coronary Artery Bypass Grafting Conduits with Clinical Implications

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