PD-L1 mediated T cell inhibition by regulatory plasma cells induced after sepsis and COVID-19
Gossez, M.; Vigneron, C.; Vandermoeten, A.; Lepage, M.; Courcol, L.; Coudereau, R.; Paidassi, H.; Jallades, L.; Lopez, J.; Kandara, K.; Ortillon, M.; Mommert, M.; Fabri, A.; Peronnet, E.; Grosjean, C.; Buisson, M.; Lukaszewicz, A.-C.; Rimmele, T.; Argaud, L.; Cour, M.; Py, B. F.; Thaunat, O.; Defrance, T.; monneret, g.; VENET, F.
Show abstract
A better understanding of sepsis-induced immunosuppression pathophysiology is desirable for the development of novel therapeutic strategies to prevent and reduce the rates of secondary infections and their associated mortality. Here we demonstrate that PD-L1+CD44+B220LowCD138+IgM+ regulatory plasma cells (PCs) are induced in a murine model of sepsis-induced immune alterations and in critically ill patients with bacterial sepsis and COVID-19. This was revealed both by detailed analysis of their phenotypical features and gene expression profile and by functional explorations comparing capacity of purified B cells and PCs to suppress T cell proliferation and IFN{gamma} secretion ex vivo. Sepsis-induced regulatory PCs exerted their suppressive function on T cells through IL-10 production and increased PD-L1 expression independently of regulatory T cells. Our findings thus reveal a novel pathophysiological mechanism of sepsis-induced immunosuppression that involves regulatory PCs. As such, these PCs constitute valid therapeutic targets to improve immune cell functions impaired by sepsis.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Innate lymphoid cell composition associates with COVID-19 disease severity 96%
- Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint 94%
- Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity 94%
Similar papers in this journal
- Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen requirements 96%
- Lasting alterations in monocyte and dendritic cell subsets in individuals after hospitalization for COVID-19 95%
- Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept 95%
Similar papers in this journal
- IL-23 tunes inflammatory functions of human mucosal-associated invariant T (MAIT) cells 94%
- Self-Collected Finger-Prick Blood for Gene Expression Profiling: Unveiling Early Immune Responses in Mild COVID-19 93%
- CIITA G-286A promoter polymorphism impairs monocytes HLA-DR expression in septic shock and is rescued by interferon-γ 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.