Preliminary reference values for Alzheimers disease plasma biomarkers in Congolese individuals with and without Alzheimers disease
Ikanga, J.; Jean, K.; Medina, P.; Patel, S. S.; Schwinne, M. C.; Epenge, E.; Gikelekele, G.; Tshengele, N.; Kavugho, I.; Mampunza, S.; Mananga, L.; Teunissen, C.; Stringer, A.; Rojas, J.; Chan, B.; Lario Lago, A.; Kramer, J.; Boxer, A.; Jeromin, A.; Gross, A.; Alonso, A.
Show abstract
BackgroundWestern countries have provided reference values (RV) for Alzheimers disease (AD) plasma biomarkers, but there are not available in Sub-Saharan African populations. ObjectiveWe provide preliminary RV for AD and other plasma biomarkers including amyloid- {beta} (A{beta}42/40), phosphorylated tau-181 and 217 (p-tau181, p-tau217), neurofilament light (Nfl), glial fibrillary acidic protein (GFAP), interleukin 1b and 10 (IL-1b and IL-10) and tumor necrosis factor (TNF) in Congolese adults with and without dementia. Methods85 adults (40 healthy and 45 dementia) over 50 years old were included. Blood samples were provided for plasma AD biomarkers A{beta}42/40 and p-tau181, p-tau217; Nfl and GFAP; IL-1b and IL-10 and TNF analyzed using SIMOA. Linear and logistic regressions were conducted to evaluate differences in biomarkers by age and gender and neurological status, and for the prediction of dementia status by each individual biomarker. RV were those that optimized sensitivity and specificity based on Youdens index. ResultsIn this sample of 85 adults, 40 (47%) had dementia, 38 (45.0%) were male, overall mean age was 73.2 (SD 7.6) years with 8.3 (5.4) years of education. There were no significant differences in age, gender, and education based on neurological status. Biomarker concentrations did not significantly differ by age except for p-tau181 and GFAP and did not differ by sex. Preliminary cutoffs of various plasma in pg/ml were 0.061 for A{beta}42/40, 4.50 for p-tau 181, 0.008 for p-tau 217, 36.5 for Nfl, 176 for GFAP, 1.16 for TNFa, 0.011 for IL-1b, and 0.38 for IL-10. All AUCs ranged between 0.64-0.74. P-tau 217 [0.74 (0.61, 0.86)] followed by GFAP [0.72 (0.61, 0.83), and Nfl [0.71 (0.60, 0.82)] had the highest AUC compared to other plasma biomarkers. ConclusionsThis study provides RV which could be of preliminary utility to facilitate the screening, clinical diagnostic adjudication, classification, and prognosis of AD in Congolese adults.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Association of Alzheimer’s Disease-related Blood-based Biomarkers with Cognitive Screening Test Performance in the Congolese Population in Kinshasa 99%
- Differences between plasma and CSF p-tau181 and p-tau231 in early Alzheimer’s disease 98%
- Alzheimer Disease Neuropathological Comorbidities Are Common in the Younger-Old 95%
Similar papers in this journal
- Association of Item-Level Responses to Cognitive Function Index with Tau Pathology and Hippocampal volume in The A4 Study 97%
- Delayed primacy recall performance predicts post mortem Alzheimers disease pathology from unimpaired ante mortem cognitive baseline 96%
- Brain Amyloid and the Transition to Dementia in Down Syndrome 95%
Similar papers in this journal
- Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort 98%
- Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer’s disease 98%
- White matter integrity is associated with cognition and amyloid burden in older adult Koreans along the Alzheimer’s disease continuum 96%
Similar papers in this journal
- A conformational variant of p53 (U-p53 AZ ) as blood-based biomarker for the prediction of the onset of symptomatic Alzheimer’s disease 96%
- Plasma brain-derived p-tau217 outperforms other p-tau species in detecting abnormal brain amyloid in an Asian cohort of older people with cerebrovascular disease burden 95%
- Identifying Proteomic Prognostic Markers for Alzheimer’s Disease with Survival Machine Learning: the Framingham Heart Study 95%