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A novel two-hit insomnia and inflammation rodent model of depressive-like behaviors

2024-08-02 psychiatry and clinical psychology Title + abstract only
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BackgroundSystemic inflammation and insomnia often co-occur in patients with depression. However, there is no suitable animal model to investigate the relationship between inflammation, sleep deprivation (SD), and depression. MethodsTo model interactions between insomnia, inflammation, and depression, we developed a novel "two-hit" rodent model of depressive-like behaviors using continuous SD followed by daily lipopolysaccharide (LPS) treatment. Control groups received SD, LPS, or sterile phosp...

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