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Gut microbiome and lichen sclerosus: a two-sample bi-directional Mendelian randomization study

2024-07-24 dermatology Title + abstract only
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(1) BackgroundRecent studies suggest a potential link between gut microbiomes (GMs) and inflammatory diseases, but the role of GMs in lichen sclerosus (LS) remains unclear. This study aims to investigate the causal relationship between GMs and LS, focusing on key GM taxa. (2) MethodsWe utilized GWAS summary statistics for 211 GM taxa and their association with 2,445 LS patients and 353,088 healthy controls, employing Mendelian randomization (MR). GWAS data for GM taxa came from the MiBioGen con...

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