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Microvascular dysfunction induces a hyperdynamic circulation; a mathematical exploration
2024-07-23
intensive care and critical care medicine
Title + abstract only
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BackgroundThe discordance between the macrocirculation and microcirculation in septic shock has been recognised but never explained. I present a novel mathematical hypothesis as to how heterogenous microcirculatory flow distribution directly induces a hyperdynamic circulation and how elevated central venous pressure induces microcirculatory dysfunction. MethodsI explore the tube law and modified Poiseuille resistance for compliant blood vessels. Using these equations a new equation is developed...
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