A systematic review of the effect of renal replacement therapy on the pharmacokinetics of co-amoxiclav
Al-Mahdi, S.; Patel, J.; Sweatman, J.; Oakley, R.; Shah, R.; Standing, J.; Lonsdale, D. O.
Show abstract
1.Background & AimCo-amoxiclav is a commonly used antibiotic. Although, the dose administered during renal replacement therapy may be subtherapeutic. This study aims to describe the current literature on the pharmacokinetics and pharmacodynamics of co-amoxiclav in patientss undergoing renal replacement therapy. MethodWe carried out a systematic review of the available literature in MEDLINE, Embase, Pubmed, and Google Scholar from inception to Oct 2023. Studies were included if they reported pharmacokinetic data on adults given amoxicillin or clavulanic acid during renal replacement therapy. ResultsSeven studies were identified which were published between 1984 to 2021. Variability was observed in the participant characteristics within the studies, the renal replacement therapy settings, the drug exposure, drug assay methods, and the analysis of the pharmacokinetic parameters. ConclusionFurther pharmacokinetic-pharmacodynamic studies are needed on co-amoxiclav during renal replacement therapy.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Prevalence and determinants of poor glycemic control among diabetic chronic kidney disease patients on maintenance hemodialysis in Tanzania 96%
- Dosage individualization proposed for anti-gout medications among the patients with gout: a bicentric study in Nepal 95%
- Efficacy of Tenapanor in Managing Hyperphosphatemia and Constipation in Hemodialysis Patients: A Randomized Controlled Trial 95%
Similar papers in this journal
- Impact of Losartan on Portal hypertension and Liver Cirrhosis: A Systematic Review 94%
- Comparison of Efficacy of Dexamethasone and Methylprednisolone in Improving the Partial Pressure of Arterial Oxygen and Fraction of Inspired Oxygen Ratio among COVID-19 Patients 93%
- A Novel Maxillofacial Technology for Drug Administration-A Randomized Controlled Trial Using Metronidazole. 93%
Similar papers in this journal
- Bacterial and Fungal Co-Infections among ICU COVID-19 Hospitalized Patients in a Palestinian Hospital: Incidence and Antimicrobial Stewardship 93%
- Atopic Biomarker Changes after Exposure to Porphyromonas gingivalis Lipopolysaccharide: A Small Experimental Study in Wistar Rat 90%
- Glibenclamide, ATP and Metformin Increases the Expression of Human Bile Salt Export Pump ABCB11 90%
Similar papers in this journal
- Serum Concentration of Continuously administered Vancomycin influences Efficacy and Safety in Critically Ill Adults: A Systematic Review 94%
- No one-size-fits-all approach: Retrospective analysis of efficacy and safety of serum concentrations of continuously administered vancomycin in critically ill adults reveals different target serum concentrations depending on disease severity 92%
- Attitudes to phage therapy among Australian infectious diseases physicians 91%
Similar papers in this journal
- Cardiovascular Complications of Modern Multiple Myeloma Therapy: Analysis of FDA Adverse Event Reporting System 91%
- Investigation on the interaction between nifedipine and ritonavir containing antivirus regimens: a physiologically-based pharmacokinetic/pharmacodynamic analysis 91%
- Sensitivity of Estimated Tacrolimus Population Pharmacokinetic Profile to Inaccurate Assumptions about Dose Timing and Absorption: An Investigation in Real-World and Simulated Data 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.