Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model ofAlzheimer's Disease
Ramonet, D.; Daerr, A.; Hallbeck, M.
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Synaptic dysfunction is an early hallmark of Alzheimers disease, characterized by the disruption of synaptic transmission and plasticity. Central to these processes is endosomal trafficking, mediated by the retromer complex, which orchestrates the movement of vesicle contents for recycling to the plasma membrane, return to the Golgi, or degradation. Variants of VPS35, the cargo recognition component of the retromer complex, have been linked to neurodegenerative diseases, including Parkinsons disease (PARK17, D620N mutation) and Alzheimers disease (L625P mutation). While substantial research has focused on Parkinsons, the role of VPS35 in Alzheimers has been less explored. This study investigates the acute neuroprotective effects of retromer-stabilizing compounds in the 5xFAD mouse model of Alzheimers. Our results reveal that stabilization of the retromer complex not only mitigates pathogenic A{beta} production mechanisms but also compensates for early synaptic dysfunction and microglial activation. Specifically, we observed significant modulation of genes involved in long-term potentiation and a reduction in abnormal retromer-associated cargos. These findings highlight the potential of retromer stabilisation as atherapeutic strategy to address fundamental pathological pathological processes in Alzheimers disease.
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