Global and regional associations of enteric infections and asthma
Ni, D.; Nanan, R.
Show abstract
Asthma is one of the most common chronic diseases globally. There are various risk factors for asthma, including respiratory infections, like rhinovirus and respiratory syncytial virus infections. Nevertheless, impacts from non-respiratory tract infections on asthma remain unresolved. Globally, enteric infections are the most common infections. Their target organ, the intestinal system, shares the same embryonic origin, the endoderm, as the respiratory tract. These led us to inspect the potential associations between enteric infections and asthma. We analyzed three independent epidemiological datasets with the cutting-edge generalized additive model (GAM). Consistently, in two regional datasets (America and Japan) and a global dataset, we found that enteric infection incidence was generally linked to increased asthma disease burden. This is the first study to our knowledge to comprehensively elucidate the positive associations between enteric infections and asthma. Our findings would be instructive to both clinical practice and mechanistic study for asthma.
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