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Antibiotic-associated neutropenia is marked by depletion of intestinal Lachnospiraceae in pediatric patients
2024-04-27
hematology
Title + abstract only
View on medRxiv
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Hematologic side effects are associated with prolonged antibiotic exposure in up to 34% of patients. Neutropenia, reported in 10-15% of patients, increases the risk of sepsis and death. Murine studies have established a link between the intestinal microbiota and normal hematopoiesis. We sought to identify predisposing factors, presence of microbiota-derived metabolites, and changes in intestinal microbiota composition in otherwise healthy pediatric patients who developed neutropenia after prolon...
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