A Comprehensive Model of Blood Flow Restriction in the Post-surgical Rat
Fosam, A.; Nakandakari, S. C. B. R.; Ohashi, Y.; Bai, H.; O'Connell, J.; Raines, A.; Chavez Miranda, I.; Dardik, A.; Allen, C.; Perry, R. J.
Show abstract
Blood flow restriction (BFR) with low-load exercise (BFR-exercise) is an increasingly popular tool used to increase muscle strength and attenuate muscle atrophy, especially after injury or surgery. However, the mechanisms underlying BFR-mediated muscle growth are not well understood. Likely contributing to the mechanistic knowledge gap, rodent models of BFR-exercise have not been well described. In this methods paper, we demonstrate a comprehensive, clinically relevant protocol to establish BFR-exercise in awake rats. This protocol includes generating a muscle loss state via bilateral ACL-R, determining targeted blood flow occlusion pressures, and performing weighted hind-limb knee extension exercises with BFR. These methods can be used for further application in mechanistic and physiologic studies of BFR-exercise.
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