Back

Bettering of Learning Activity through Elevated P-Cresol Levels in the Brain: Insights from Active Avoidance Testing in Wistar Rats

Tevzadze, G.; Zhuravliova, H.; Kikvidze, Z.; Kiknadze, N.; Shetekauri, T.; Tkemaladze, N.

2024-03-28 animal behavior and cognition
10.1101/2024.03.25.586517 bioRxiv
Show abstract

It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of cognitive abilities in rats. In this study, we aimed to investigate the impact of augmenting p-cresol levels in the brain on learning. The Active Avoidance Test was employed to assess learning capabilities. The results, with a high level of confidence, indicated that rats with an increased concentration of p-cresol in the brain exhibited superior task performance and accelerated learning compared to the control group.

Matching journals

The top 6 journals account for 50% of the predicted probability mass.

1
PLOS ONE
● 5266 papers in training set
Top 14%
13.3%
2
Behavioural Processes
○ 18 papers in training set
Top 0.1%
13.0%
3
Behavioural Brain Research
○ 77 papers in training set
Top 0.1%
10.0%
4
Neurochemistry International
○ 10 papers in training set
Top 0.1%
6.9%
5
Frontiers in Pharmacology
○ 111 papers in training set
Top 0.3%
5.7%
6
Scientific Reports
○ 3612 papers in training set
Top 15%
5.6%
50% of probability mass above
7
Progress in Neuro-Psychopharmacology and Biological Psychiatry
○ 48 papers in training set
Top 0.1%
4.1%
8
European Journal of Neuroscience
○ 189 papers in training set
Top 0.8%
3.5%
9
Physiology & Behavior
○ 31 papers in training set
Top 0.1%
3.3%
10
European Journal of Pharmacology
○ 15 papers in training set
Top 0.1%
3.3%
11
Brain and Behavior
○ 43 papers in training set
Top 0.3%
2.5%
12
Neuropharmacology
○ 68 papers in training set
Top 0.5%
1.8%
13
Frontiers in Behavioral Neuroscience
○ 49 papers in training set
Top 0.6%
1.4%
14
International Journal of Neuropsychopharmacology
◐ 14 papers in training set
Top 0.2%
1.2%
15
Neuroscience
○ 97 papers in training set
Top 1%
1.2%
16
Neurobiology of Learning and Memory
○ 40 papers in training set
Top 0.3%
1.2%
17
International Journal of Molecular Sciences
○ 494 papers in training set
Top 14%
0.9%
18
Brain Sciences
○ 55 papers in training set
Top 2%
0.9%
19
Frontiers in Neuroscience
○ 256 papers in training set
Top 6%
0.9%
20
eLife
● 5828 papers in training set
Top 63%
0.9%
21
Frontiers in Psychiatry
○ 87 papers in training set
Top 2%
0.9%
22
Biomedicine & Pharmacotherapy
○ 42 papers in training set
Top 1%
0.9%
23
Biomedicines
○ 67 papers in training set
Top 3%
0.6%
24
Hormones and Behavior
○ 45 papers in training set
Top 0.4%
0.6%
25
Heliyon
○ 152 papers in training set
Top 9%
0.6%
26
Psychopharmacology
○ 69 papers in training set
Top 0.9%
0.6%
27
eneuro
● 439 papers in training set
Top 8%
0.6%
28
Biomolecules
○ 100 papers in training set
Top 3%
0.6%