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Mitochondria-Associated Membranes Are Not Altered In Immune Cells In T2D

Hart, S. N.; Lenin, R.; Sturgill, J.; Kern, P. A.; Nikolajczyk, B. S.

2024-03-29 immunology
10.1101/2024.03.25.586170 bioRxiv
Show abstract

Metabolism research is increasingly recognizing the contributions of organelle crosstalk to metabolic regulation. Mitochondria-associated membranes (MAMs), which are structures connecting the mitochondria and endoplasmic reticulum (ER), are critical in a myriad of cellular functions linked to cellular metabolism. MAMs control calcium signaling, mitochondrial transport, redox balance, protein folding/degradation, and in some studies, metabolic health. The possibility that MAMs drive changes in cellular function in individuals with Type 2 Diabetes (T2D) is controversial. Although disruptions in MAMs that change the distance between the mitochondria and ER, MAM protein composition, or disrupt downstream signaling, can perpetuate inflammation, one key trait of T2D. However, the full scope of this structures role in immune cell health and thus T2D-associated inflammation remains unknown. We show that human immune cell MAM proteins and their associated functions are not altered by T2D and thus unlikely to contribute to metaflammation. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=92 SRC="FIGDIR/small/586170v1_ufig1.gif" ALT="Figure 1"> View larger version (24K): org.highwire.dtl.DTLVardef@1a281f1org.highwire.dtl.DTLVardef@1025corg.highwire.dtl.DTLVardef@42259eorg.highwire.dtl.DTLVardef@b3bbb1_HPS_FORMAT_FIGEXP M_FIG C_FIG

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