The Landscape of RAD51D in Chinese Ovarian Cancer Patients: Prevalence, Correlation with HRD Score, and Correlation with Efficacy
Sun, T.; Zhang, M.; Xu, X.; Liang, Y.; Chen, J.; Li, Q.; Zeng, J.; Li, Z.; Dong, Y.; Yin, R.
Show abstract
Human genome is continuously threatened by endogenous and exogeneous sources of DNA damage, DNA damage repair (DDR) mechanisms are vital for genome instability and cancer prevention. Homologous recombination repair (HRR) is one of the most important DDR mechanisms because of its high-fidelity. BRCA1/2 have long been the best characterized HRR genes, but other non-BRCA1/2 HRR genes should not be overlooked. In this study, we illustrate that RAD51D is an important non-BRCA1/2 HRR gene in Chinese ovarian cancer patients, from perspectives including prevalence (2.9% patients mutated in RAD51D, 72.7% of RAD51D mutations were bi-allelic loss-of-function [BILOF]), correlation with HRD score (P=0.295 for RAD51D mutation, P=0.087 for RAD51D BILOF), and correlation with efficacy (progression-free survival: HR=0.685 P=0.069 for RAD51D mutation, HR=0.571 P=0.054 for RAD51D BILOF).
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Genomic profile in TGCT Mexican patients reveals a potential biomarker of sensitivity to platinum-based therapy 95%
- Hormone Receptor-status Prediction in Breast Cancer Using Gene Expression Profiles and Their Macroscopic Landscape 94%
- A novel role for the tumor suppressor gene ITF2 in lung tumorigenesis and chemotherapy response 94%
Similar papers in this journal
- ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer 93%
- RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer 93%
- FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy 92%
Similar papers in this journal
- Circulating serum miRNAs predict response to platinum chemotherapy in high-grade serous ovarian cancer 94%
- Comprehensive analysis of potential immunotherapy genomic biomarkers in 1,000 Chinese patients with cancer 93%
- Detecting PI3K and TP53 Pathway Disruptions in Early-Onset Colorectal Cancer Among Hispanic/Latino Patients 92%
Similar papers in this journal
- Systems biomedicine of primary and metastatic colorectal cancer reveals potential therapeutic targets 93%
- Patient stratification of clear cell renal cell carcinoma using the global transcription factor activity landscape derived from RNA-seq data 93%
- BNIP3 upregulation characterizes cancer cell subpopulation with increased fitness and proliferation 92%
Similar papers in this journal
- A comprehensive algorithmic dissection yields biomarker discovery and insights into the discrete stage-wise progression of colorectal cancer 94%
- DNMT family induced down-regulation of NDRG1 via DNA methylation and clinicopathological significance in gastric cancer 94%
- Novel Driver Strength Index highlights important cancer genes in TCGA PanCanAtlas patients 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.