Sex-dependent associations between human milk oligosaccharides and malaria outcomes in breastfeeding Ugandan children
Mwangi, V. I.; Owalla, T. J.; Moukarzel, S.; Okurut, E.; Yonemitsu, C.; Bode, L.; Egwang, T. G.
Show abstract
Human milk oligosaccharides (HMOs), whose compositions vary between secretor and non-secretor mothers, protect breastfeeding children against various diseases. We investigated the relationship between HMOs in Ugandan secretor mothers and malaria outcomes in their children. Malaria outcomes in breastfeeding children followed up over seven months were classified as malaria-free and asymptomatic, mild, or severe malaria. A single human milk sample collected from each mother was analyzed for HMOs. Significantly higher 2fucosyllactose (2FL) and lacto-N-fucopentaose I (LNFP I) concentrations were observed in mothers of malaria-free children, and significantly higher lacto-N-tetraose (LNT) concentrations were observed in mothers of children with asymptomatic malaria. Concentrations of five HMOs, 3-fucosyllactose (3 FL), 3sialyllactose (3SL), difucosyllactose (DFLac), lacto-N-fucopentaose II (LNFP II), and sialyllacto-N-tetraose b (LSTb); and two HMOs, difucosyllacto-N-tetrose (DFLNT) and fucosyllacto-N-hexaose (FLNH) were significantly higher in mothers of malaria-infected children and children with severe malaria, respectively. Sex-dependent associations were observed for some HMOs.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A cohort study on the duration of Plasmodium falciparum infections during the dry season in The Gambia 93%
- Multi-functional antibodies are induced by the RTS,S malaria vaccine and associated with protection in a phase I/IIa trial 92%
- Transcriptome analysis of Plasmodium falciparum isolates from Benin reveals specific gene expression associated with cerebral malaria 92%
Similar papers in this journal
- Signatures of divergent antimalarial treatment responses in peripheral blood from infants and adults in Malawi 92%
- Analysis of nucleic acids extracted from rapid diagnostic tests reveals a significant proportion of false positive test results associated with recent malaria treatment 92%
- Integrative Transcriptomic and Machine Learning Approaches to decipher Mitochondrial Gene Regulation in severe Plasmodium vivax Malaria 91%
Similar papers in this journal
- Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand 94%
- Induction, decay, and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children 94%
- Reduced risk of placental parasitaemia associated with complement fixation on Plasmodium falciparum by antibodies among pregnant women 93%
Similar papers in this journal
- Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein 93%
- Plasmodium falciparum immunodominant IgG epitopes in subclinical malaria 93%
- Plasmodium falciparum genomic surveillance reveals spatial and temporal trends, association of genetic and physical distance, and household clustering 93%
Similar papers in this journal
- Impact of a rapid decline in malaria transmission on antimalarial IgG subclasses and avidity 94%
- Reduced placental transfer of antibodies against microbial and vaccine antigens in HIV-infected women in Mozambique 94%
- Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.