Treatment Outcomes of Doxycycline Use for Musculoskeletal Infections: A Systematic Review and Meta-Analysis
Aljadani, R.; Gonzalez Bravo, C.; Bojang, M.; Carvour, M. L.
Show abstract
Doxycycline is among the most commonly used antibiotics for the treatment and long-term suppression of musculoskeletal infections such as osteomyelitis and periprosthetic joint infection. We systematically reviewed clinical trials and cohort studies that examined outcomes of musculoskeletal infections treated with doxycycline. Eligible studies were published in Medline or Embase in English before March 2, 2021. Eleven reports were included; eight addressed medical/non-dental infections, and three addressed dental infections. Brucella was the most frequently studied organism in the non-dental studies. Random-effects meta-analyses showed no significant difference in Brucella relapse risk after six weeks of treatment with 200 mg doxycycline compared to 400 mg ofloxacin daily (pool risk ratio: 0.94, 95% confidence interval: 0.2 - 4.45, I2 =L0%). Despite a large number of case reports, case series, and cross- sectional studies on this topic, few studies investigated doxycycline treatment outcomes; and evidence was largely limited to rare infections such as Brucella.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Protocol for the systematic review of the Pneumocystis jirovecii -associated pneumonia in non-HIV immunocompromised patients 92%
- CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection 92%
- Osteoblast-osteoclast co-cultures: a systematic review and map of available literature 92%
Similar papers in this journal
- Exploring Risk Factors for Comorbid Depression in Osteoarthritis: A Scoping Review Protocol 92%
- Effectiveness and clinical relevance of kinesio taping in musculoskeletal disorders: A protocol for an overview of systematic reviews and evidence mapping 92%
- The devil is in the details: Reporting and transparent research practices in sports medicine and orthopedic clinical trials 91%
Similar papers in this journal
- Circulatory Cytokines and Chemokines Profile in Human Coronaviruses: A systematic review and meta-analysis 89%
- Host-Microbial Interactions in Systemic Lupus Erythematosus and Periodontitis 88%
- Comparative Effectiveness of mRNA-1273 and BNT162b2 COVID-19 Vaccines in Immunocompromised Individuals: A Systematic Review and Meta-Analysis Using the GRADE Framework 87%
Similar papers in this journal
- Altered microRNA Expression Correlates with Reduced TLR2/4-Dependent Periodontal Inflammation and Bone Resorption Induced by Polymicrobial Infection 93%
- Diversity of Treponema denticola and other oral treponeme lineages in subjects with periodontitis and gingivitis 91%
- Comparative Diagnostic Evaluation of Real-Time PCR and Culture for Detecting Pathogens in Podiatric Wound Infections 90%
Similar papers in this journal
- Bacterial Sensitivity to Chlorhexidine and Povidone-Iodine Antiseptics Over Time: A Systematic Review and Meta-Analysis of Human-Derived Data 93%
- Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients 91%
- Detailed Analysis of Surface Infection Barrier on Hands: Relationship with Morbidity to Infection Diseases and Identification of Antimicrobial Components 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.