The molecules lost NEW COMPOUNDS BINDING AT THE HISTAMINE SITE OF THE NMDA RECEPTOR (NMDA(HA)R)
Armand, V.
Show abstract
NMDA receptor ligands have been the target of intensive research for the treatment of psychotic diseases and central nervous system diseases. Our group published the characterization of the NMDA receptor histamine site. We developed modulators for this site, about 500 drugs were tested and we finally have a partial agonist FUBn293 with a nanomolar affinity and also an antagonist ST-579 with a nanomolar affinity. We suggest that agonists at the (NMDA(HA)R) constitute an innovative class of antipsychotics for the treatment of schizophrenia and other neurological or psychiatric disorders.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- The wide spectrum anti-inflammatory activity of andrographolide in comparison to NSAIDs: a promising therapeutic compound against the cytokine storm 95%
- 17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier 93%
- Effects of sub-chronic, in vivo administration of sigma-1 receptor ligands on platelet and aortic arachidonate cascade in streptozotocin-induced diabetic rats 93%
Similar papers in this journal
- Synthesis and structural optimization of 2,7,9-trisubstituted purin-8-ones as FLT3-ITD inhibitors 94%
- Identification of a cardiac glycoside exhibiting favorable brain bioavailability and potency for reducing levels of the cellular prion protein 93%
- Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues 93%
Similar papers in this journal
- A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light 94%
- Multiple ligand recognition sites in free fatty acid receptor 2 (FFAR2) direct distinct neutrophil activation patterns 93%
- Larixol is not an inhibitor of Gαi containing G proteins and lacks effect on signaling mediated by human neutrophil expressed formyl peptide receptors 93%
Similar papers in this journal
- Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo 94%
- Pharmacological Characterisation of Novel Adenosine Receptor A3R Antagonists 93%
- Discovery of Z1362873773: A Novel Fascin Inhibitor from a Large Chemical Library for Colorectal Cancer 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.