Advancing primary care for childhood pneumonia: a machine learning-based approach to prognosis and case management

BackgroundPneumonia is the leading cause of preventable mortality under five years of age. Appropriate case management is as essential as disease prevention interventions, especially in primary care settings. Computer science has been used accurately and widely for pneumonia diagnosis; however, prognosis studies are relatively low. Herein, we developed a machine learning-based clinical decision support system tool for childhood pneumonia to provide prognostic support for case management. MethodsWe analyzed data from 437 children admitted to our clinic with a pneumonia diagnosis between 2014 and 2020. Pediatricians encoded the raw dataset according to candidate features. Before the experimental study of the machine learning algorithms of Pycaret, SMOTE-Tomek was utilized for managing imbalanced datasets. The feature selection was made by examining the SHAP values of the algorithm with the highest performance and re-modeled with the most important clinical features. We optimized hyperparameters and employed ensemble methods to develop a robust predictive model. ResultsOptimized models predicted pneumonia prognosis with %77-88 accuracy. It was shown that severity could be determined over %84 by five clinical features: hypoxia, respiratory distress, age, Z score of weight for age, and antibiotic usage before admission. ConclusionsIn this experimental study, we demonstrated that contemporary data science methods, such as oversampling, feature selection, and machine learning tools, are promising in predicting the critical care need of patients. Even in small-size samples like our study, ML methods can reach current wisdom. HighlightsO_LIPneumonia accounts for 14% of mortality in children under 5, with over 740,000 deaths in 2019 alone. C_LIO_LIWHO and UNICEFs GAPPD aims to cut mortality rates by focusing on vaccinations, sanitation, breastfeeding, and addressing pediatric HIV. C_LIO_LIAccurate diagnosis and timely treatment can reduce pneumonia mortality by up to 28%, yet diagnosing can be challenging. C_LIO_LIMany in underdeveloped regions lack access to essential equipment and trained staff, exacerbating mortality rates. C_LIO_LIData science and machine learning offer promising solutions for pneumonia management, especially in LMICs, with a focus on prognostic support. C_LI