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Disparities in ABO Blood Type Determination Across Diverse Ancestries: A Systematic Review and Validation in the All of Us Research Program
2024-02-24
genetic and genomic medicine
Title + abstract only
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BackgroundABO blood types have widespread clinical use and robust associations with cardiovascular disease. Many studies determine ABO blood types using tag single nucleotide polymorphisms (tSNPs) to characterize functional variation. However, tSNPs with low linkage disequilibrium (LD) may promote misinference of ABO blood types, particularly in diverse populations. MethodsBibliographic databases were searched for studies (2005-2022) using tSNPs to determine ABO alleles in accordance with PRISM...
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