Comparison of lipidomic profiles sampled with electroporation-based biopsy from healthy skin, squamous cell carcinoma, and basal cell carcinoma.
Louie, L.; Wise, J.; Berl, A.; Shir-az, O.; Kravtsov, V.; Yakhini, Z.; Shalom, A.; Golberg, A.; Vitkin, E.
Show abstract
Incidence rates of cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are increasing, while the current diagnostic process is time consuming. We introduce a high-throughput sampling approach, termed e-biopsy, utilizing electroporation-based biopsy for efficient collection of tissue lipids. Our study identified 168 lipids using ultra-performance liquid chromatography and tandem mass spectrometry (UPLC-MS-MS). The e-biopsy technique demonstrated its ability to profile the human skin lipidome. Comparative analysis revealed 27 differentially expressed lipids (p<0.05). The observed trend of lipidomic profiles was low diglycerides in cSCC and BCC, elevated phospholipids in BCC, and increased lyso-phospholipids in cSCC compared to healthy skin samples. These findings contribute to understanding skin cancers and highlight the potential of e-biopsy for lipidomic analysis in skin tissues.
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