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Magnetic Microtweezers for High-Throughput Bioseparation in Sub-Nanoliter Droplets

Dumas, S.; Alexandre, L.; Richerd, M.; Serra, M.; Descroix, S.

2024-01-22 bioengineering
10.1101/2024.01.18.576187 bioRxiv
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Multiomics studies at single-cell level require small volume manipulation, high throughput analysis and multiplexed detection, characteristics that droplet microfluidics can tackle. However, the initial step of molecules bioseparation remains challenging. Here, we describe a unique magnetic device to trap and extract magnetic particles in sub-nanoliter droplets, for compartmentalisation of detection steps. Relying on electrodeposition of NiFe structures and microfluidic manipulation, this technology has allowed the purification of genetic material at single-cell scale and was able to reach an extraction rate of 72% for a sample of purified oligonucleotides.

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