Cross-Center Validation of Deep Learning Model for Musculoskeletal Fracture Detection in Radiographic Imaging: A Feasibility Study
Hruby, R.; Kvak, D.; Dandar, J.; Atakhanova, A.; Misar, M.; Dufek, D.
Show abstract
Fractures, often resulting from trauma, overuse, or osteoporosis, pose diagnostic challenges due to their variable clinical manifestations. To address this, we propose a deep learning-based decision support system to enhance the efficacy of fracture detection in radiographic imaging. For the purpose of our study, we utilized 720 annotated musculoskeletal (MSK) X-rays from the MURA dataset, augmented by bounding box-level annotation, for training the YOLO (You Only Look Once) model. The models performance was subsequently tested on two datasets, sampled FracAtlas dataset (Dataset 1, 840 images, nNORMAL = 696, nFRACTURE = 144) and own internal dataset (Dataset 2, 124 images, nNORMAL = 50, nFRACTURE = 74), encompassing a diverse range of MSK radiographs. The results showed a Sensitivity (Se) of 0.910 (95% CI: 0.852-0.946) and Specificity (Sp) of 0.557 (95% CI: 0.520-0.594) on the Dataset 1, and a Se of 0.622 (95% CI: 0.508-0.724) and Sp of 0.740 (95% CI: 0.604-0.841) on the Dataset 2. This study underscores the promising role of AI in medical imaging, providing a solid foundation for future research and advancements in the field of radiographic diagnostics.
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