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Reverse mutational scanning of spike BA.2.86 identifies the epitopes contributing to immune escape from polyclonal sera

2024-01-03 infectious diseases Title + abstract only
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The recently detected Omicron BA.2.86 lineage contains more than 30 amino acid mutations relative to BA.2. BA.2.86 and its JN.1 derivative evade neutralization by serum antibodies of fully vaccinated individuals. In this study, we elucidate epitopes driving the immune escape of BA.2.86 and JN.1 via pseudovirus neutralization. Thus, we have generated 33 BA.2.86 mutants, each reverting a single mutation back to BA.2. We use this library in an approach that we call reverse mutational scanning to de...

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