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Deep immune profiling of chronic rhinosinusitis in allergic and non-allergic cohorts using mass cytometry

2023-12-22 respiratory medicine Title + abstract only
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BackgroundChronic rhinosinusitis (CRS) is characterized by persistent nasal and paranasal sinus mucosa inflammation. It comprises two phenotypes, namely CRS with nasal polyps (CRSwNP) and without (CRSsNP). CRSwNP can be associated with asthma and hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) in a syndrome known as NSAID-exacerbated respiratory disease (N-ERD). Furthermore, CRS frequently intertwines with respiratory allergies. ObjectiveThis study investigated the phenotypic...

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