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GeneExt: a gene model extension tool for enhanced single-cell RNA-seq analysis

Zolotarov, G.; Grau-Bove, X.; Sebe-Pedros, A.

2023-12-07 bioinformatics
10.1101/2023.12.05.570120 bioRxiv
Show abstract

Incomplete gene models negatively impact single-cell gene expression quantification. This is particularly true in non-model species where often gene 3' ends are inaccurately annotated, while most scRNA-seq methods only capture the 3' transcript region. This results in many genes being incorrectly quantified or not detected. GeneExt leverages scRNA-seq data to refine gene annotations, enhancing biological interpretation and cross-species comparisons of cell type expression atlases.

Published in Bioinformatics (predicted rank #1) · training set

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