Changes in the physical behaviour of older adults during the 13 weeks GOTO intervention explain a boost in immuno-metabolic health.

BackgroundThe aging population faces numerous health challenges, with sedentary behavior and decreased physical activity being paramount. We explore the physical behaviour of older adults in the GOTO combined lifestyle intervention study and its related immuno-metabolic health effects. MethodsThe research utilized accelerometers and machine learning to assess physical activity behaviours during a 13-week program of increased physical activity and decreased calorie intake. Subsequently, the association of variation in physical behaviour with immuno-metabolic health parameters is investigated cross-sectionally at baseline and longitudinally using sex-stratified linear regression and linear mixed regression respectively. ResultsParticipants exhibited physical behaviors similar to their age-matched peers from the UK-Biobank. Interestingly, gender-based differences were evident, with men and women showing distinct daily physical behavioural patterns. At baseline, a positive correlation was found between higher physical behavior and a healthier immune-metabolic profile, particularly in men. The longitudinal changes depict an overall boost in activity levels, predominantly among women. While increasing general activity and engaging in intense exercises proved advantageous for physical health, the immune-metabolic health benefits were more pronounced in men. ConclusionThe short-term GOTO intervention underscores the significance of regular physical activity in promoting healthy aging even in middle to older age. Gender differences in behavior and health benefits deserve much more attention though. Our results advocate the broader implementation of such programs and emphasize the utility of technology, like accelerometers and machine learning, in both monitoring and promoting active lifestyles among older adults.