Back

Dormant Mycobacterium tuberculosis reactivates ex vivo in blood from HIV infected individuals

Kalyan, M.; Agarwal, S.; Sharma, A.; Verma, I.

2023-11-18 biochemistry
10.1101/2023.11.18.566455 bioRxiv
Show abstract

Reports of tuberculosis in Human Immunodeficiency Virus infected patients despite high CD4+ T-cell counts suggest different mechanisms of reactivation. In vitro developed dormant Mycobacterium tuberculosis H37Rv were cultured in HIV blood and normal blood. Colony forming units analysis was performed and expression of mycobacterial Resuscitation Promomoting Factor genes was analyzed by qRT-PCR. The in vitro developed dormant M. tb resuscitated in HIV blood as evident from increase in CFUs and up-regulation in the expression of mycobacterial rpf genes. Reactivation of dormant tubercle bacilli following HIV infection in spite of high CD4+ T-cell counts could be due to some viral or host factors which needs further studies.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
PLOS ONE
● 5266 papers in training set
Top 2%
39.8%
Similar papers in this journal
2
Pathogens
○ 56 papers in training set
Top 0.1%
6.8%
Similar papers in this journal
3
Scientific Reports
○ 3612 papers in training set
Top 15%
5.5%
Similar papers in this journal
50% of probability mass above
4
Access Microbiology
● 25 papers in training set
Top 0.1%
4.9%
Similar papers in this journal
5
Antimicrobial Agents and Chemotherapy
● 187 papers in training set
Top 0.8%
3.2%
Similar papers in this journal
6
Life
○ 29 papers in training set
Top 0.1%
3.2%
7
F1000Research
○ 88 papers in training set
Top 1%
2.1%
8
International Journal of Molecular Sciences
○ 494 papers in training set
Top 6%
2.1%
9
Heliyon
○ 152 papers in training set
Top 3%
1.7%
10
Epidemiology and Infection
◐ 89 papers in training set
Top 1%
1.7%
11
BioMed Research International
○ 28 papers in training set
Top 0.9%
1.7%
12
Viruses
○ 332 papers in training set
Top 3%
1.5%
13
Virology
○ 61 papers in training set
Top 0.8%
1.5%
14
PLOS Neglected Tropical Diseases
● 466 papers in training set
Top 4%
1.5%
15
mSphere
● 302 papers in training set
Top 7%
0.8%
16
Biochemical and Biophysical Research Communications
○ 84 papers in training set
Top 2%
0.8%
17
Frontiers in Cellular and Infection Microbiology
○ 109 papers in training set
Top 4%
0.6%
18
Journal of Medical Virology
○ 140 papers in training set
Top 3%
0.6%
19
Journal of Medical Microbiology
● 25 papers in training set
Top 0.8%
0.6%
20
Microbiology Spectrum
● 469 papers in training set
Top 11%
0.6%
21
Cells
○ 249 papers in training set
Top 8%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.