Immunity to non-dengue flaviviruses impacts dengue virus IgG ELISA specificity in Cambodia
Odio, C.; Yek, C.; Hasund, C.; Man, S.; Ly, P.; Nhek, S.; Chea, S.; Lon, C.; Voirin, C.; Huy, R.; Leang, R.; Huch, C.; Oliveira, F.; Manning, J.; Katzelnick, L.
Show abstract
Seroprevalence studies are the gold standard for disease surveillance, and serology was used to determine eligibility for the first licensed dengue vaccine. However, expanding flavivirus endemicity, co-circulation, and vaccination complicate serology results. Among 713 healthy Cambodian children, a commonly used indirect dengue virus IgG ELISA (PanBio) had a lower specificity than previously reported (94% vs. 100%). Of those with false positive PanBio results, 46% had detectable neutralizing antibodies against other flaviviruses, with the highest frequency against West Nile virus (WNV). Immunity to non-dengue flaviviruses can impact dengue surveillance and potentially pre-vaccine screening efforts.
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