Basigin mediation of Plasmodium falciparum red blood cell invasion does not require its interaction with monocarboxylate transporter 1
King, N. R.; Freire, C. M.; Touhami, J.; Sitbon, M.; Toye, A. M.; Satchwell, T. J.
Show abstract
Plasmodium falciparum invasion of the red blood cell is reliant upon the essential interaction of PfRh5 with the host receptor protein basigin. Basigin exists as part of one or more multiprotein complexes, most notably through interaction with the monocarboxylate transporter MCT1. However, the potential requirement for basigin association with MCT1 and the wider role of basigin host membrane context and lateral protein associations during merozoite invasion has not been established. Using genetically manipulated in vitro derived reticulocytes, we demonstrate the ability to uncouple basigin ectodomain presentation from the transmembrane domain-mediated interaction with MCT1. Merozoite invasion of reticulocytes is unaffected by disruption of basigin MCT1 interaction and by removal or replacement of the basigin transmembrane helix. Therefore, presentation of the basigin ectodomain at the red blood cell surface, independent of its native association with MCT1 or other interactions mediated by the transmembrane domain, is sufficient to facilitate merozoite invasion.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A rhomboid protease, EhROM1, regulates the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica 92%
- Postpartum cytokine shifts and IL-10-mediated immune suppression in malaria-infected primigravid women 92%
- Salubrinal induces fetal hemoglobin expression via the stress-signaling pathway in human sickle erythroid progenitors and sickle cell disease mice 92%
Similar papers in this journal
- Utility of thromboelastography with platelet mapping (TEG-PM) for monitoring platelet transfusion in qualitative platelet disorders 91%
- Quantitative super-resolution imaging of platelet degranulation reveals differential release of VWF and VWF propeptide from alpha-granules 91%
- Phage Display Broadly Identifies Inhibitor-reactive Regions in von Willebrand Factor 91%
Similar papers in this journal
- Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays 95%
- Choice of lipid supplementation for in vitro erythroid cell culture impacts reticulocyte yield and characteristics 93%
- Platelet Derived Growth Factor Receptor β (PDGFRβ) is a Host Receptor for the human malaria parasite adhesin TRAP 93%
Similar papers in this journal
- CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes 94%
- The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection 92%
- The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming 92%
Similar papers in this journal
- Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5 92%
- DOT1L methyltransferase regulates the calcium influx in erythroid progenitor cells in response to erythropoietin 91%
- Excess BAFF Alters NR4As Expression Levels and Breg Function of Human Precursor-like Marginal Zone B-cells in the Context of HIV-1 infection 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.